Alzheimer’s Tied to Mutation Harming Immune Response

Alzheimer’s researchers and drug companies have for years concentrated on one hallmark of Alzheimer’s disease: the production of toxic shards of a protein that accumulate in plaques on the brain.

But now, in a surprising coincidence, two groups of researchers working from entirely different starting points have converged on a mutated gene involved in another aspect of Alzheimer’s disease: the immune system’s role in protecting against the disease. The mutation is suspected of interfering with the brain’s ability to prevent the buildup of plaque.

The discovery, researchers say, provides clues to how and why the disease progresses. The gene, known as TREM2, is only the second found to increase Alzheimer’s risk substantially in older people.

“It points very specifically to a potential metabolic pathway that you could intervene in to change the course of Alzheimer’s disease,” said William Thies, chief medical and scientific officer of the Alzheimer’s Association.

Much work remains to be done before scientists understand precisely how the newly discovered gene mutation leads to Alzheimer’s, but already there are some indications from studies in mice. When the gene is not mutated, white blood cells in the brain spring into action, gobbling up and eliminating the plaque-forming toxic protein, beta amyloid. As a result, Alzheimer’s can be staved off or averted.

But when the gene is mutated, the brain’s white blood cells are hobbled, making them less effective in their attack on beta amyloid.

People with the mutated gene have a threefold to fivefold increase in the likelihood of developing Alzheimer’s disease in old age.

The intact gene, says John Hardy of University College London, “is a safety net.” And those with the mutation, he adds, “are living life without a safety net.” Dr. Hardy is lead author of one of the papers.

The discovery also suggests that a new type of drug could be developed to enhance the gene’s activity, perhaps allowing the brain’s white blood cells to do their work.

“The field is in desperate need of new therapeutic agents,” said Alison Goate, an Alzheimer’s researcher at Washington University in St. Louis who contributed data to Dr. Hardy’s study. “This will give us an alternative approach.”

The fact that two research groups converged on the same gene gives experts confidence in the findings. Both studies were published online Wednesday in The New England Journal of Medicine. “Together they make a good case that this really is an Alzheimer’s gene,” said Gerard Schellenberg, an Alzheimer’s researcher at the University of Pennsylvania who was not involved with the work.

The other gene found to raise the odds that a person will get Alzheimer’s, ApoE4, is much more common and confers about the same risk as the mutated version of TREM2. But it is still not clear why ApoE4, discovered in 1993, makes Alzheimer’s more likely.

Because the mutations in the newly discovered gene are rare, occurring in no more than 2 percent of Alzheimer’s patients, it makes no sense to start screening people for them, Dr. Thies said. Instead, the discovery provides new clues to the workings of Alzheimer’s disease.

To find the gene, a research group led by Dr. Kari Stefansson of deCODE Genetics of Iceland started with a simple question.

“We asked, ‘Can we find anything in the genome that separates those who are admitted to nursing homes before the age of 75 and those who are still living at home at 85?’ ” he said.

Scientists searched the genomes of 2,261 Icelanders and zeroed in on TREM2. Mutations in that gene were more common among people with Alzheimer’s, as well as those who did not have an Alzheimer’s diagnosis but who had memory problems and might be on their way to developing Alzheimer’s.

The researchers confirmed their results by looking for the gene in people with and without Alzheimer’s in populations studied at Emory University, as well as in Norway, the Netherlands and Germany.

The TREM2 connection surprised Dr. Stefansson. Although researchers have long noticed that the brain is inflamed in Alzheimer’s patients, he had dismissed inflammation as a major factor in the disease.

“I was of the opinion that the immune system would play a fairly small role, if any, in Alzheimer’s disease,” Dr. Stefansson said. “This discovery cured me of that bias.”

Meanwhile, Dr. Hardy and Rita Guerreiro at University College London, along with Andrew Singleton at the National Institute on Aging, were intrigued by a strange, rare disease. Only a few patients had been identified, but their symptoms were striking. They had crumbling bones and an unusual dementia, sclerosing leukoencephalopathy.

“It’s a weird disease,” Dr. Hardy said.

He saw one patient in her 30s whose brain disease manifested in sexually inappropriate behavior. Also, her bones kept breaking. The disease was caused by mutations that disabled both the copy of TREM2 that she had inherited from her mother and the one from her father.

Eventually the researchers searched for people who had a mutation in just one copy of TREM2. To their surprise, it turned out that these people were likely to have Alzheimer’s disease.

They then asked researchers around the world who had genetic data from people with and without Alzheimer’s to look for TREM2 mutations.

“Sure enough, they had good evidence,” Dr. Hardy said. The mutations occurred in one-half of 1 percent of the general population but in 1 to 2 percent of patients with Alzheimer’s disease.

“That is a big effect,” Dr. Hardy said.

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Staying smart about end-of-year healthcare

November is one of the most important months for health benefits. And it's half over.

This month is a time of open enrollment, when many workers sign up for next year's health insurance. Deadlines are a big deal, and you don't want to miss one.

But once you're set for 2013, experts say, shift your attention back to 2012 and those use-'em-or-lose-'em benefits awaiting you.

"Anything employees can do to accelerate elective care at year end allows them to get the full benefit" of their health plans, says Mike Thompson of consulting firm PricewaterhouseCoopers.

Here is a look at ways experts recommend to avoid leaving money on the table.

Make the most of your deductibles. Deductibles — the money you're required to pay out of pocket before insurance covers all or part of your healthcare services — are becoming more prevalent and more expensive.

If you've met your annual deductible for 2012, now may be a good time to schedule any medical treatment you've been delaying.

"At the beginning of the calendar year, everything resets with new out-of-pocket limits and deductibles. It's better to get any discretionary services done by the end of the year so you're in benefit and can get expenses reimbursed," Thompson says.

Today, a person with single coverage pays $1,097 on average in medical bills before insurance kicks in. According to Menlo Park, Calif.-based Kaiser Family Foundation, 72% of workers enrolled in an employer plan are on the hook for a deductible, up from about half in 2006. The amount of deductibles has also risen 88% during the same period.

And don't forget the possible savings of ordering prescription drugs before year end. You may be able to order a 90-day supply now to get you through the first few months of the year.

"It may make sense to accelerate your purchases of prescription drugs toward the end of the year because you know you're going to need them and they won't be subject to the deductible," Thompson says.

Be careful with your calculations. It should be easy to determine whether you've met your deductible for the year. But it can get tricky when you consider a lag, sometimes months long, between the time your doctor submits a claim and your insurance company processes it. You and your insurer may not have the same tally with regard to how much you've spent during this benefit year.

"My recommendation is to work with your broker's office to get an accurate assessment as to where you are in your benefit," says Dave Morgan, senior employee benefits advisor with Morris and Garritano Insurance Services in San Luis Obispo.

If you get health insurance at work, talk with your benefits or human resources department for assistance.

Coordinate your care. There's a caveat to the recommendation that you squeeze in care before New Year's Day. Consider first, Morgan says, the "choreography" of your care and how that may affect costs.

For example, knee surgery is likely to require months of follow-up physical therapy. Would it be less expensive to have your surgery fully covered in 2012 and pay cash for your physical therapy starting in 2013 before your deductible is met? Or, might holding off on the surgery until early 2013 result in less cash out of your pocket given the overall course of treatment?

To reap the greatest benefit from your health plan, do the math on both scenarios.

Splitting care between one year and the next can make sense, especially for dentistry. Dental plans typically come with an annual maximum benefit of $1,000 to $1,500. If you're in need of an expensive procedure, it may make financial sense to get started in December and finish in January.

"There's no perfect way to navigate all of this," says Martin Rosen, executive vice president of Health Advocate, a patient advocacy organization based in Pennsylvania. The key, Rosen says, is to "understand how your particular plan works and the leverage points throughout the year for which timing does make a difference."

Use your annual benefits. Be sure to take advantage of benefits with calendar limits, such as semi-annual dental cleanings, free eyeglasses or contact lenses. The same goes for preventive health services.

"When you get that preventive care, you're going to have a sense of what issues you'll face with your health in the coming year," Morgan says. That may better inform your 2013 health benefit choices as well as how much money to set aside in a Flexible Spending Account, or FSA, for next year.

Use all your FSA money. Unlike Health Savings Accounts, or HSAs, which allow you to roll over pretax dollar savings from one year to the next, FSAs have a shelf life. Typically you need to fully spend the account by year's end or you'll lose the money left over.

On average, people forfeit about $120 each year, says Jody Dietel, chief compliance officer at San Mateo, Calif.-based WageWorks, which administers employer-based tax advantaged accounts.

The IRS allows a grace period of 2 1/2 months, or by mid-March of the following year, to spend FSA money. And, according to Dietel, 75% of her company's 22,000 employer clients offer employees a grace period. But the length of time varies widely among employers, so check with your plan administrator to learn what's allowed.

Also, keep in mind that some rules have recently changed because of health reform. "For example, with an FSA you can't get over-the-counter drugs without a prescription from the doctor," Rosen says. To see a list of eligible expenses, go to the FSA Store at http://www.fsastore.com and click on the eligibility list at the bottom of the home page.

Many people lose money simply by failing to claim the expenses they already have, Dietel says. "Go and see if there is unfound money someplace," she says.

For example, if you fill all your prescriptions at the same pharmacy, ask the pharmacist to print a list of the co-pays for this year, and submit any outstanding charges to your Flexible Spending Account.

One final piece of advice before you pick up the phone to schedule your end-of-year doctor visit: Follow your health plan's rules, Morgan says. Stay in your health plan's network of doctors and hospital, and "make sure you have the proper pre-authorization in place."

business@latimes.com

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If soldier killed Afghan civilians in rampage, did he act alone?

JOINT BASE LEWIS MCCHORD, Wash. — The case against U.S. Army Staff Sgt. Robert Bales appeared at first to be horribly simple: Days after a bomb blew off the leg of a friend in southern Afghanistan, the 39-year-old combat veteran picked up his rifle, a pistol and a grenade launcher, walked to two villages and allegedly conducted a one-man campaign of vengeance, killing 16 civilians and wounding six more.

But by the time a weeklong hearing wound up Tuesday in a military courtroom, one of the Army's highest-profile war crimes from Afghanistan raised almost as many questions as it answered.

If Bales acted alone, why were shots heard coming from one of the villages 20 minutes after he was spotted returning to the base for the first time?

Why was a witness who claimed to have seen two U.S. soldiers killing her husband while helicopters flew overhead not brought in to testify?

Why were the crime scenes so very different — at one house, a surgical execution of the head of the family, while at the next house, 11 men, women and children were shot and possibly stabbed, their bodies piled in a heap and burned?

The Article 32 hearing, held to determine whether there was evidence to hold the serviceman for a court-martial, drew a portrait not just of a rogue soldier, defense lawyers said. It revealed a U.S. combat outpost at which soldiers spent their evenings drinking alcohol, snorting Valium and taking steroids, all three of which Bales apparently had done before asking a friend to "take care of my kids" and setting out into the darkness outside the base perimeter, laughing.

"We have a dysfunctional, drinking and drugging … team," civilian defense lawyer Emma Scanlan said in her closing argument.

"We can't isolate Sgt. Bales within a bubble," Scanlan said, noting that he was under the supervision of Special Forces officers. "They are the command. They are in charge. And they are terrible at it."

Army prosecutors claim Bales acted alone and with chilling rationality: walking to the village of Alkozai, where he is accused of killing four people and wounding six, coming back to the base and telling a friend what he had done, then venturing out again to the village of Najiban, where he is accused of killing 12.

When Bales returned to Camp Belambay the second time, he admitted to friends he had done some "sick" things, and told them they would thank him when fighting season got underway again during warmer weather later in the spring, said prosecutor Maj. Robert Stelle.

"Terrible, terrible things happened. That is clear. The second thing that is clear is that Staff Sgt. Bales did it," Stelle said.

He urged investigating officer Col. Lee Deneke to recommend a full court-martial and that it be tried as a capital case, with the possibility of the death penalty. Bales committed "the worst, most despicable crime a human being can commit: murdering children in their own homes," Stelle said.

If Deneke recommends a court-martial, a lengthy process of mental health evaluations and further forensic reports will follow. Defense lawyers have pledged there will be a full exploration of the medical care Bales received at the Madigan Army Medical Center for an earlier traumatic brain injury.

The hospital south of Seattle was the subject of an investigation this year for tossing aside diagnoses of post-traumatic stress disorder, making it harder for those soldiers to receive follow-up medical care.

In the year before the shootings, Scanlan said, Bales had received an exemplary evaluation, in which he was praised for "a strong moral compass, never wavering from what was right."

What went wrong?

Scanlan suggested part of the answer might lie in the steroids and sleep aids Bales was taking, along with the Jack Daniels he drank with two friends on the evening before the killings as they watched "Man on Fire," a movie about a former CIA operative who executes a violent campaign of revenge.

"They drank a ton, and they were all drunk," Scanlan said, noting that testimony showed that one of the soldiers who'd been drinking with Bales that night, Cpl. David Godwin, was stumbling, slurring his words and smelled like alcohol four hours later.

The prosecution said Bales had plenty of time to reach both villages and return at the end of the night with his clothing and weapons covered in blood. Before he left, prosecutors said, he had discussed his frustration with the Army's lack of response to the bomb that blew off his friend's leg; after his arrest, he reminded one soldier of an Afghan machine gunner the unit had faced earlier.

"That's not going to happen again," Bales said, according to Staff Sgt. Ross O'Rourke.

Prosecutors also established that DNA from at least one of the women killed at the home of Haji Mohammed Wazir in Najiban was found on Bales' clothing.

Yet defense lawyers continue to raise questions about whether Bales was the only one responsible — whether one person could have killed so many people in so many locations in one night.

A lot of the evidence suggests otherwise, Scanlan said, pointing to an agent from the Army's Criminal Investigations Command who said that Masuma Dawood, whose husband was shot, told her that two soldiers had killed her husband.

Army officials said Dawood did not testify because of "cultural differences," and the reluctance of Afghan families to allow a woman to testify in an American courtroom, even by remote video from Afghanistan. But sources in Afghanistan have told the Los Angeles Times that Dawood was, in fact, willing to testify.

Scanlan said the timeline laid out by prosecutors also raises questions, beginning with the Afghan guard who testified that he checked his watch, and was certain that the U.S. soldier he saw — returning from the initial killings in Alkozai, prosecutors allege — had returned to Camp Belambay at 1:30 a.m.

The shots heard from the direction of Alkozai didn't stop till 1:50 a.m., the defense attorney said.

"I don't know what that means," Scanlan said. "But one thing it means is, if you believe what the government is telling you, that Sgt. Bales is the one who came back through that wire at 1:30, then somebody else was firing for another 20 minutes."

kim.murphy@latimes.com

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'Gangnam Style' star joins Madonna onstage at MSG

NEW YORK (AP) — Madonna has gone "Gangnam Style."

Korean pop star PSY joined the pop icon Tuesday night during her second show this week at Madison Square Garden. They danced to his pop culture anthem "Gangnam Style" and to her jam "Music" in front of nearly 20,000.

Madonna said PSY flew "all the way from Frankfurt, Germany this morning." She also said she was a big fan of the rapper and loved his suit, which was bright red.

He added that he's had a lot of experiences in the last few months, and that performing at MSG with Madonna topped his list.

Madonna also collected money for those affected by Superstorm Sandy. Fans threw money onstage while she sang "Like a Virgin." She said she collected $3,000 at Monday's show.

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Recipes for Health: Roasted Eggplant and Chickpeas — Recipes for Health

Andrew Scrivani for The New York Times

Eggplant is always a good, substantial vegetable to use for a vegetarian main dish. The chickpeas and the feta provide plenty of protein. Vegans can leave out the feta and substitute sugar or agave nectar for the honey.

 

1/4 cup extra virgin olive oil

2 garlic cloves, minced

1 28-ounce can chopped tomatoes, with juice, pulsed to a coarse purée

1 teaspoon mild honey (more to taste)

1/4 to 1/2 teaspoon cinnamon, to taste

Salt to taste

1 large or 2 medium eggplants (about 1 1/4 pounds), cut into 1/3-inch-thick slices

3 cups cooked chickpeas (2 cans, drained and rinsed, or, 1 1/2 cups dried – about 3/4 pound

4 ounces feta, crumbled (3/4 cup)

1 teaspoon dried oregano, preferably Greek or Turkish

 

1. Make the tomato sauce. Heat 1 tablespoon of the olive oil in a heavy skillet or wide saucepan over medium heat, and add the garlic. Cook, stirring, until it smells fragrant, about 30 seconds, and add the tomatoes, honey, salt to taste and cinnamon. Cook over medium heat until the tomatoes have cooked down and the sauce is fragrant, about 20 minutes. Taste and adjust seasonings.

2. Meanwhile, heat the oven to 425 degrees. Line a baking sheet with aluminum foil and brush the boil with olive oil. Place the eggplant slices on the baking sheet, salt lightly and brush with olive oil. Place in the oven and bake 20 minutes, or until eggplant is lightly browned and soft all the way through. Remove from the heat. Fold the aluminum foil over and crimp the edges together so that the eggplant steams as it cools. Do this in batches if you need more than one baking sheet. Turn the oven down to 350 degrees.

3. Oil a 2-quart baking dish or gratin. Place the chickpeas in the baking dish and stir in 1 cup of the tomato sauce. Layer the eggplant over the chickpeas and top with the remaining tomato sauce. Sprinkle the feta over the top and drizzle on any remaining olive oil. Sprinkle with the oregano and cover tightly with foil. Bake 30 minutes. Uncover and bake another 10 minutes, until the dish is bubbling.

Yield: 6 servings

Advance preparation: The eggplant slices can be cooked up to a day ahead. Hold in the refrigerator, covered. The tomato sauce will keep for 3 days in the refrigerator and freezes well.

Nutritional information per serving: 366 calories; 16 grams fat; 4 grams saturated fat; 2 grams polyunsaturated fat; 8 grams monounsaturated fat; 17 milligrams cholesterol; 44 grams carbohydrates; 14 grams dietary fiber; 431 milligrams sodium (does not include salt to taste); 15 grams protein

Martha Rose Shulman is the author of “The Very Best of Recipes for Health

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McAfee proclaims innocence, alters look to evade Belize police

In another twist to an already bizarre story, the founder of the McAfee anti-virus software company contacted an American journalist Tuesday to maintain his innocence and chronicle how he has been evading police.

John McAfee, 67, has been missing since Sunday morning, when his next-door neighbor Gregory Faull, 52, was found dead in a pool of blood in a Belize beachfront home. On Tuesday, McAfee contacted Wired contributing editor Joshua Davis and said he's on the run, scared for his life — and did not commit murder.

Quiz: Test your knowledge about airport security

Belize police on Sunday said they wanted to question McAfee in what they described as a homicide investigation.

Davis tweeted the salient details, including the former CEO saying he feared being killed in custody and — when power was cut to his hiding spot — the grim summation that "this is it."

"Under no circumstances am I going to willingly talk to the police in this country," McAfee reportedly told the editor at the technology magazine. "You can say I'm paranoid about it but they will kill me, there is no question. They've been trying to get me for months. They want to silence me. I am not well liked by the prime minister. I am just a thorn in everybody's side."

As police raided his compound Sunday, McAfee told the writer that he hid in the sand with a cardboard box over his head so he could breathe, and spent the night on a mattress infested with lice. He has continued to change locations, according to the writer's tweets.

Quiz: Test your knowledge of business news

"It was extraordinarily uncomfortable," McAfee told Wired. "But they will kill me if they find me."

Belize police urged McAfee to come forward Tuesday, saying he is only a person of interest, rather than a murder suspect. The police said they have detained an individual but declined to discuss details, citing the ongoing investigation.

Police have a vendetta against him, McAfee told Wired, and are trying to drive him out of Belize.

McAfee made his fortune when the anti-virus company that bears his name went public in 1992. He netted $100 million two years later when he sold his stock. Over the next 20 years, $100 million dropped to $4 million as he lost money to real estate investments, bad business ventures and bonds linked to Lehman Bros.

About five years ago, McAfee moved to a beachfront compound on Ambergris Caye island to lower his taxes, said Daniel Guerrero, the mayor of the town closest to the crime scene.

Belize police arrested McAfee in April and charged him with unlicensed drug manufacturing and possession of an unlicensed weapon, according to police news releases. McAfee said at the time that he planned to sue for false arrest, alleging the police arrested him because he refused to donate money to a local official.

Last week, Faull — a retired contractor from Florida — filed a complaint against McAfee with the local city council, Guerrero said. McAfee's security guards were trespassing on Faull's property, and McAfee's guard dogs were attacking passers-by, Faull's complaint said.

Faull's two-story apartment showed no signs of forced entry. A laptop and iPhone were missing, and police found a 9-millimeter Luger shell casing on the stairs, spokesman Raphael Martinez said.

Police believe McAfee is still in the country but have had little success in tracking him down, perhaps due in part to the latest information he shared with Davis — that he has radically altered his appearance.

laura.nelson@latimes.com

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Historic theater in Beverly Hills an empty shell

The renowned designer had a mission: to "transform this Wilshire Boulevard cracker box into a sumptuous palace."

So Joseph J. Musil ordered up red velour seats, gold sconces, a sunburst ceiling and a lobby carpeted in crimson for the 1993 renovation of the Fine Arts Theater in Beverly Hills. Shimmery black curtains swept back to reveal the giant screen. The place thrived as a venue for small premieres, drawing A-listers on any given night and plaudits from nearby residents.

But it wasn't enough. Unable to stay afloat, the Fine Arts closed in 2009. An Indian company's plan to reopen it to screen Bollywood films fell through. The theater became an empty shell.

And so it remains. Some supporters worry that the Fine Arts will never function as a theater again. Back on the market for $4 million, the Fine Arts is at the mercy of an era and economy that make a tiny, one-screen movie theater a risky investment. And while former patrons view the theater with nostalgia, and a few prospective buyers have made inquiries, no investors have stepped up. Historic as the theater is, it is not quite a landmark.

"It's a big shame, but you know, it's a change in the entertainment system," said Brian Dunne of NAI Capital, who has the listing. "People are going to the big multiplexes with food courts and parking. They want it to be more of a social experience. I don't mean to say this is a dinosaur going nowhere. This place has a lot of charms. We need somebody who wants to keep its tradition alive."

That tradition dates to 1936, when it was built. Named the Regina Theater, it would go on to generate a wealth of lore. Actor Peter Lorre once stopped in to catch a showing of "M," the German film that kick-started his career. He fell asleep.

In 1948 it was renamed the Fine Arts Theater and hosted the premiere of "The Red Shoes." Invited guests included Susan Hayward, Joan Crawford, Ava Gardner and Shirley Temple.

Vittorio Cecchi Gori's film production company bought the theater in the early 1990s and spearheaded the Musil renovation. Cecchi Gori's 1997 production "Life Is Beautiful" went on to win several Oscars. Its director and star, Roberto Benigni, arrived one day at the Fine Arts to practice crawling over theater seats, a move he repeated the following evening at the Dorothy Chandler Pavilion when accepting his best actor award.

Known as a low-key place that showed foreign films or indie flicks, the Fine Arts attracted cinephiles and celebrities.

Casey Rocke, who worked as the theater's manager and film projectionist, recalled the days when Mel Brooks and Anne Bancroft arrived on double dates with Carl and Estelle Reiner. An employee once jokingly carded Charlton Heston for the senior discount. Even Hollywood's younger generation made their way to the ticket booth. Cameron Diaz and Leonardo DiCaprio were both good-humored during its pre-credit card days, dashing to an ATM across the street.

"We had a solid audience and always booked something no one else had," Rocke, 34, said. "The theater didn't make a killing, but it didn't lose money."

At one point Landmark Theatres was operating the place; then Cecchi Gori rented it out as a screening room. The current owner, Bhupendra Kumar Modi, who lives in Singapore and has a home in Beverly Hills, is selling the Fine Arts after deciding its operation didn't fit his company's business plan.

City officials and staff have spoken in favor of keeping the site a cinema. Michele McGrath, senior planner for Beverly Hills, said city officials have been looking at how to invigorate the neighborhood and have even talked of creating a theater district.

"I think the city cares about theaters in general — they're part of our cultural heritage," she said.

Area residents say they have felt the loss. But most see it simply as a sign of the times.

"It seemed like it was part of our neighborhood and that we had a stake in it," said Brenda Castiel, who has lived within walking distance of the theater for two decades. "I would love for it to remain a theater, but I imagine it's not economically viable."

Across from a gas station and an auto repair shop just west of La Cienega Boulevard, the theater is easy to miss on traffic-clogged Wilshire Boulevard. Display cases that once held movie posters are empty and the marquee blank.

Inside, boxes of Red Vines and Junior Mints still linger at the concession stand. A purple couch fringed in gold awaits a visitor. Although the entry shows some wear and tear, the auditorium, with its rows of plush seats and gold and silver decor, still exudes glamour. It is in need of a ruler but remains the sumptuous palace Musil envisioned.

corina.knoll@latimes.com

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Head of Microsoft’s Windows unit steps down

(Reuters) – Microsoft Corp said the head of its flagship Windows division and the driving force behind Windows 8, Steven Sinofsky, will be leaving the company with immediate effect, days after the software giant launched the Surface tablet.

Sinofsky, who presented at the launch of the Windows 8 operating system in New York City last month, will be succeeded by Julie Larson-Green, who will head the Windows hardware and software division, the company said in a statement.

Tami Reller will remain chief financial officer and chief marketing officer and will assume responsibility for the business of Windows.

Both executives will report directly to Microsoft CEO Steve Ballmer, Microsoft said.

At the launch event in October, Sinofsky and his team showed off a range of devices running Windows 8 from PC makers such as Lenovo Group Ltd and Acer Inc, but devoted most of their energy to the second half of the presentation and the Surface tablet, the first computer Microsoft has made itself.

(Reporting by Sakthi Prasad and Nicola Leske; Editing by Edmund Klamann)

Tech News Headlines – Yahoo! News

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Storm volunteers mingle with stars at Glamour fest

NEW YORK (AP) — Sandra Kyong Bradbury was star struck. She had just spied Supreme Court Justice Ruth Bader Ginsburg a few feet away.

"How can you top that?" asked Bradbury, a New York City neonatal nurse who had helped evacuate infants from a hospital that lost power during the height of Superstorm Sandy. She was amazed that she was being honored at the same event as a Supreme Court justice — the annual Glamour Women of the Year awards, where stars of film, TV, fashion and sports share the stage with lesser-known women who have equally impressive achievements to their name.

Few events bring together such an eclectic group of honorees, not to mention presenters. At the Carnegie Hall ceremony Monday night, HBO star Lena Dunham, creator of "Girls" and a heroine to a younger generation, was introduced by Chelsea Handler and paid tribute in her speech to Nora Ephron, who died earlier this year. Ethel Kennedy was praised by her daughter, Rory, who has made a film about her famous mother. Olympic gymnast Gabby Douglas, 17, was honored along with swimming phenom Missy Franklin, also 17, and other Olympic athletes, introduced by singer Mary J. Blige and serenaded by American Idol winner Phillip Phillips. Singer-actress Selena Gomez was lauded by her friend, the actor Ethan Hawke.

But the most moving moments of the Glamour awards, now in their 22nd year, are often those involving people of whom the audience hasn't heard. This year, the most touching moment came when one honoree, Pakistani activist and filmmaker Sharmeen Obaid-Chinoy, brought onstage a woman who'd been the victim of an acid attack in her native Pakistan. Obaid-Chinoy won this year's documentary short Oscar for a film about disfiguring acid attacks on Pakistani women by the men in their lives.

The evening carried reminders of Superstorm Sandy, with Newark, N.J. Mayor Cory Booker introducing some 20 women who'd been heavily involved in storm relief work. "They held us together when Sandy tried to blow us apart," Booker said. The women worked for organizations like the American Red Cross, but also smaller volunteer groups like Jersey City Sandy Recovery, an impromptu group formed by three women in Jersey City, N.J., who wanted a way to help storm-ravaged communities.

Singer-rapper Pharrell Williams introduced one of his favorite architects, the Iraqi-born Zaha Hadid, 62, who designed the aquatic center for the London Olympics and is now at work on 43 projects around the world.

Activist Erin Merryn was honored for her work increasing awareness of child sex abuse — a horror she had endured during her own childhood. A law urging schools to educate children about sex abuse prevention, Erin's Law, has now passed in four states. "I won't stop until I get it passed in all 50 states," Merryn insisted in her speech.

Vogue editor Anna Wintour saluted a fellow fashion luminary, honoree Annie Leibovitz, the creator of so many iconic photographs over the years. Jenna Lyons, the president of J. Crew, got kind words from her presenter, former supermodel Lauren Hutton. Chelsea Clinton brought up a stageful of women from across the country who had been involved in politics this year, noting that, while there is still a long way to go, progress was made in 2012.

The lifetime achievement award went to Ginsburg, 79, who made a few quips about being honored by a fashion magazine. "The judiciary is not a profession that ranks very high among the glamorously attired," the justice said. She also noted that although she was only the second female Supreme Court justice (Sandra Day O'Connor came first), she was the first justice to be honored by Glamour.

An affectionate tribute to the late Ephron followed, with three actresses — Cynthia Nixon, and two Meryl Steep daughters, Mamie and Grace Gummer, reading from a graduation speech she had given at Wellesley College.

Actress Dunham, in her speech, touched on politics and expressed her own relief that President Barack Obama had won re-election, saying she felt it was crucial for reproductive freedom and other issues of women's rights. "I wanted control of my womb before I really knew what my womb was," she quipped.

After the ceremony, which was presided over by Glamour editor in chief Cindi Leive, honorees and presenters headed to a private dinner. There, Sandy volunteers mingled with the stars. One woman, Lynier Harper, had spent six nights during Sandy at the Brooklyn YMCA where she works, taking care of other people. "When I finally went back home, my house was totally destroyed," she said. She has moved in with her sister while she seeks a new home.

A group of seven nurses came from New York University's Langone Medical Center, which lost power during the storm. The neonatal intensive care nurses had to carry the babies down nine flights of stairs, in the dark, squeezing oxygen into their lungs, to get them to safety.

And there were the three women from Jersey City Sandy Recovery, sinking in the proximity to the so many impressive people.

"I just shook Ruth Bader Ginsburg's hand," exulted one of them, Candice Osborne. "How awesome!"

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Lance Armstrong Cuts Officials Ties With His Livestrong Charity

In the wake of being stripped of his seven Tour de France titles for doping, Lance Armstrong last week cut all official ties with Livestrong, the charity he founded 15 years ago while he was treated for testicular cancer.

On Nov. 4, he resigned from the organization’s board of directors; he had previously stepped down as the chairman of the board Oct. 17. He has distanced himself from the charity to try to protect it from any damage caused by his doping controversy, the new board chairman, Jeff Garvey, said in a statement.

“Lance Armstrong was instrumental in changing the way the world views people affected by cancer,” Garvey said. “His devotion to serving survivors is unparalleled, and for 15 years, he committed himself to that cause with all his heart.”

Garvey said that the Armstrong family had donated nearly $7 million to the foundation and that the organization under Armstrong had raised close to $300 million to serve cancer survivors.

Last month, the United States Anti-Doping Agency made public its evidence in its doping case against Armstrong, saying he had doped and encouraged his teammates to dope so they could help him win races. He was subsequently barred from Olympic sports for life and was stripped of all the cycling titles he won from August 1998 on.

Since then, Armstrong has spent several weeks in Hawaii, out of the public eye. On Saturday, though, he posted a photograph on Twitter showing him at home in Austin, Tex. He is lounging on a couch with his seven yellow Tour jerseys framed on the wall in the background.

In the post, he said, “Back in Austin and just layin’ around.” The photograph had more than 400,000 page views as of Monday evening, with many people posting negative comments on the page.

“Lance, you have no moral conscious and it’s obvious many of your followers don’t either,” said one person who went by the Twitter handle “irobot,” who also posted that Armstrong needed “professional help.”

A person posting under the name “Aumann” said: “An art thief enjoying all his da Vincis.”

Other people posted words of support, including many who said they still thought Armstrong was the top cyclist in history.

“TomShelton” said of Armstrong’s seven Tour titles, “You earned all 7 of them no matter what is being said about you!”

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